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KMID : 0984920090110020104
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Journal of Skin Barrier Research
2009 Volume.11 No. 2 p.104 ~ p.114
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Toll-Like receptor expression of human skin fibroblast is affected by histamine
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Won June-Ho
Won Young-Ho
Jang Su-Jeong
Park Jong-Seong
Kim Seong-Jin
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Abstract
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Fibroblasts are mesenchymally derived cells responsible for the synthesis and degradation of various connective tissue components along with soluble mediators. There has been a few researches concerning toll-like receptors in fibroblasts until now. This study is aimed to find the quantitative expression of TLR 1 to 10 in human skin fibroblasts, and to explore any influence of histamine a well-known factor engaged in dermal inflammation. It was found that all 10 TLRs were expressed in fibroblast. Interestingly TLR 4, 5 and 10 expression were increased after 2, 6 hours of histamine treatment during culture, respectively. However the expressions of TLR 2, 3, 6, 7, 8, 9 were decreased after 6 hours of histamine treatment. Among the decreased expression of TLRs, TLR 7 and 8 showed a persistently decreasing unique pattern. All these change in expression was antagonized by diphenhydramine treatment. Thus, these results suggest a new
role of histamine in inflammatory reaction mediated by TLRs.
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KEYWORD
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Toll-Like receptor, Fibroblast, Histamine
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